Lactoferrin and Dr Naidu


Dr. Naidu and Lactoferrin,  a summary of what it is and how it affects our system.

Series II

Lactoferrin (LF)  is a metal-binding glycoprotein  [a carbohydrate and a protein] that play essential roles in the body. For instance, in the immune system almost all of the key molecules involved in the immune response  are glycoproteins. Lactoferrin is present in mother's milk and secretions of the exocrine glands (mainly the digestive, respiratory, and reproductive systems). LF provides mucosal protection against invading micro-organisms and other toxins. LF is credited with an impressive list of physiological implications which is listed below. What we are concerned with in this article is its role with bone health.

  • Gastrointestinal System: Critical for nutrient absorption LF has a tremendous impact on bone metabolism, intestinal absorption of iron, zinc, copper, manganese and other essential trace elements.
  • Cardiovascular System: Systemic levels of LF which produces a higher concentration of neutrophils when there is inflammation may play a role in countering the negative effects of catabolism in the skeletal system. LF has also been shown to modulate the secretion of osteolytic cytokines, resulting in its direct effect on the activity and development of bone cells.
  • Skeletal System: Lactoferrin stimulates the production of pre-osteoblastic (precursor cells). Reduced apoptosis (programmed cell death) of these precursor cells acts as a survival factor in which the end result is an increase in local bone formation (in-vivo) [even with short term use]. Research sows that LF can positively be used as bio-replenishment to reverse osteoporosis and restore skeletal strength.

 "I was diagnosed with advanced osteopenia a few months ago. I tried the Boniva for one month which made me very sick, and in much pain.  I decided to look for another answer to bone loss. It was at a bone health meeting at Terri Oberto's office where I learned that I could improve my bone health naturally. I thought I would give it a try. I have been using the Osteodenx, Caldenx, and Lactoferrin for almost three months. I just had my bone density and physical (November 2010) and my doctor was pleasantly surprised to see that my T score has improved and that I actually have gained 1/2 inch in height!! I will definitely keep up with this program and hope to reverse the damage of aging back to a young person again!"

Lactoferrin stimulates the growth of chondrocytes (bone cartilage) which consists of collagen and proteoglycans. A decline in chondrocyte production may lead to a loss of cartilage (a lubricant for joints) which can lead to osteoarthritis (inflammation). Because of the effect LF has on the inflammatory process including microbial and anti-inflammatory protection, immuno-modulation occurs.

TABLE: Lactoferrin- Multifunctional Protein for Bone-Replenishment    ©AS Naidu

Specific Function Possible Role in Bone health
Metal binding and transport Provides essential bone minerals (eg. zinc, chromium)
Anti-microbial activity Evades bone infections (eg. osteomyelitis)
Anti-oxidant activity Prevents bone and joints from free radical damage
Anti-tumor activity Controls metastatic bone conditions (eg. osteosarcoma)
Anti-inflammatory activity Protects from inflammatory bone dis-eases (eg. OA, RA)
Prebiotic activity Maintains healthy gut for optimal bone nutrient absorption
Opsonic activity Scavenges foreign bodies that may harm bone tissue
DNA binding activity Bone development and growth
Bone growth factor Stimulates osteoblasts to form new bone matrix
Sperm-coating antigen Facilitate sexual transfer of genetic information
Intestinal absorption Maintains healthy gut for bone mineral transport
Immuno-modulation Protects the bone from antigen-mediated immune responses
Complement activation Helps combat rheumatoid arthritis
Platelet activation Participates in bone repair processes (eg. healing of fractures)
Feed-back regulation Controls various bone homeostatic pathways
Down-regulation of myelopoiesis Controls blood cell production in the bone marrow
Regulation of collagenase Maintains healthy cartilage in bone joints




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21 Reasons to drink NingXia Red daily

1. The Ningxia Wolfberry provides ample antioxidants to strengthen the immune system. Anti-oxidants permeate cell walls and attack free radicals before they damage the DNA of the cell nucleus.

2. Antioxidants of this berry fight arteriosclerosis and atherosclerosis--aiding the circulatory system---including the heart.

3. The Ningxia Wolfberry is powerful in helping the liver function properly. The liver is one of the most vital organs in the body--it's our cleansing machine.

4. Helps the eyes--cataracts, glaucoma, and visual acuity. This berry contains a complete array of antioxidant carotenoids including beta-carotene and zeaxanthin. In fact the Ningxia Wolfberry has the highest source of carotenoids in all known foods. Beta-carotene is best known as a nutrient for the retina.

5. Cancer Help. The main constituent of the wolfberry is Lycium Barbarum Polysaccharide (LBP), and according to studies in China, LBP helps cancer patients rebuild their white blood cell count, enhancing phagocytes and the activity of natural killer cells which bind to cancerous cells, as well as improving major classes of T-cells. "...increase the antibody reaction to the T cell-antigen."

6. More Cancer Help. Acetone extract from the Ningxia Wolfberry inhibits gene mutation, Some scientists say the fruit is a good supplement to prevent liver cancer. 4 Also, studies show objective regression of cancer in patients with malignant melanoma, renal cell carcinoma, colorectal cancer, lung cancer, and others. Results also indicated LBP may be used as an adjuvant in the bio-therapy of cancer.

7. Minerals and vitamins act as enzymes and co-factors in the digestion process.

8. Studies on seniors in China produced amazing results (many people live beyond 100 years of age in wolfberry growing areas). Increases in Super Oxide Dismutase (SOD) the hemoglobin were found in serum in all participants. In other words wolfberry ".......may help slow the aging process."

9. Protects against the free radical attack on mitochondrial DNA--our energy furnaces inside each cell. Antioxidants fight against mitochondrial destabilization.

10. Helps lower blood sugar--and in many tests at least stabilizes blood sugar.

11. It is important that cell walls maintain their malleability for nutrients to cross this membrane. The free radical scavengers found in the Ningxia Wolfberry strengthen the cell wall and support efficient transport of flavonoid nutrients in the cell and waste products out of the cell.

12. Strengthens the brains neuro-transmitters against pervasive fee radical activity, thus fighting against dementia and other forms of memory loss.

13. Promotes a sense of well-being, and has had noticeable results in tests and anxiety. The tissues of the body (including the brain) are assisted in avoiding oxidative stress.

14. Has a B-Vitamin complex essential to the body. In addition these vitamins are vital for converting food to energy.

15. Cells need to communicate, especially those in the brain and nervous system. The synaptic responses are protected and fortified by the same polyphenols (flavonoids) that this berry uses to protect itself.

16. Provides powerful anti-fungal and anti-bacterial action because it contains solavetivone (an amino acid). Properties in the food fight viruses---it's anti-viral.

17. Reduces pain caused by inflammation because the berry contains Beta-Sitosteral, a remarkable anti-inflammatory.

18. The Ningxia Wolfberry is high in protein (more than whole wheat), an essential cellular building block.

19. The Ningxia Wolfberry, unlike most berries, contains natural vitamin E--a restorative antioxidant with too many health benefits to list here.

20. A healthier romantic life. The wolfberry increases overall health performance, including sexual response. One herbalist wrote, "Wolfberry can make a young wolf out of an old man.''

21. This berry dubbed ''A complete body health motivator'' has many unique polysaccharides, not found in any plant on the planet.


1. Ben cao Gang Mu; Physicians Handbook; Ming Dynasty 1368-1644 AD
2. Benzie, Dr. Iris F., MD; Hong Kong Polytechnic University; 2005; The British Journal of Medicine.
3. Guifan, Huang, et al; Immune Boosting Effects from Fu Fan Wu 2: Yang Zong Wan; (Chinese Herbs, 1990, 12 (6):27
4. In-Vitro Anti-Mutation Effect of Lycium Barbarum Polysaccharide (LBP). (Chinese Herbs, 1991)
5. Journal of Chinses Herbal Medicine; 1994. Note: Japanese Research Scientists also stated the wolfberry could inhibit the growth of cancer cells.